![]() Nausea, vomiting, thrombocytopenia (2.4 percent), myelosuppression Streptococcus pneumoniae (penicillin sensitive) Staphylococcus aureus (MSSA and MRSA) Streptococcus pyogenes Streptococcus agalactiae vancomycin-resistant Enterococcus faecium Inhibits protein synthesis at initiation step. Other contributing factors that have led to changes in virulence, and thus, the development of resistance to antibiotics, include societal changes (e.g., population growth and migration), an increasing number of immunosuppressed patients, the globalization of food supplies and changes in the way food is grown and produced, human behavior (e.g., widespread and frequent international travel), and environmental changes (including long-standing use of antibiotics in animal husbandry and agriculture). 2 The increasing problem of antimicrobial resistance in the hospital and the community parallels the over-prescribing of antibiotics. It is estimated that 50 million pounds of antibiotics are taken annually in the United States 1 and 30 percent of antibiotic prescriptions are for respiratory tract infections, more than one half of which were probably viral. Their widespread and unnecessary use is the greatest contributing factor. Multiple factors contribute to the development of resistance to antibiotics. Judicious use of this medication should help physicians treat patients with multidrug-resistant infections. As a nonselective inhibitor of monoamine oxidase, caution is recommended when used with adrenergic or serotonergic agents (e.g., tyramine, dopamine, pseudoephedrine, and selective serotonin reuptake inhibitors). It is generally well tolerated, with myelosuppression being the most serious adverse effect. It has been approved for certain gram-positive infections including certain drug-resistant enterococcus, staphylococcus, and pneumococcus strains. ![]() It is well absorbed with high bioavailability that allows conversion to oral therapy as soon as the patient is clinically stable. Linezolid disrupts bacterial growth by inhibiting the initiation process of protein synthesis-a mechanism of action that is unique to this class of drugs. Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. While the choices available for the management of gram-positive, drug-resistant bacterial infections are becoming limited, antimicrobial resistance is becoming increasingly problematic because of the widespread overuse of antibiotics.
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